Haemostatic Disorders in Sickle Cell Disease Subjects in Nigeria: A Review of Literature
Kingsley Akaba *
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Marcus Inyama
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Timothy Ekwere
Department of Haematology and Blood Transfusion, University of Uyo Teaching Hospital, Uyo, Nigeria
Obinna Iheanacho
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Ekpeyong Bassey
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Ushie Godwin
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Hogan Archibong
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
Efiok Efiok
Department of Haematology and Blood Transfusion, University of Calabar Teaching Hospital, Calabar, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Background: Sickle cell disease (SCD) is an autosomal recessive disorder that is characterised with chronic anaemia and painful crisis. SCD is associated with hypercoagulability or prothrombotic state that can predispose to thromboembolic complications with increasing morbidity and mortality.
Aim: This study aimed to show the various documented haemostatic disorders and possible thromboembolic complications among SCD subjects in Nigeria.
Methods: A comprehensive literature search was performed using the internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant information.
Findings and Conclusion: There is a paucity of information on this subject in Nigeria, and there are inconsistencies in the available studies.
Haemostatic disorders in sickle cell disease are conditions that are associated with increased mortality and morbidity. Further research on the level of natural anticoagulant is required to verify the correlation between haemostatic disorders and thromboembolic complications in SCD subjects in Nigeria.
Keywords: Haemostatic disorders, sickle cell disease, hypercoagulability, Nigeria