Coagulation Parameters among Women with Obstetric Complications in Specialist Hospital Sokoto, Nigeria
Onuigwe Festus Uchechukwu *
Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Khadija Bello Tudu
Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Erhabor Osaro
Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Buhari Hauwa Ali
Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Bagudo Aliyu Ibrahim
Department of Haematology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Amilo Grace Ifechukwudebelu
Department of Haematology, Faculty of Medicine, College of Health Science, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Ibeh Nancy Chitogu
Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background and Aim: Obstetric complications are part of the leading causes of maternal mortality worldwide. This study was carried out to investigate the effect of complications on the Prothrombin time (PT), activated partial thromboplastin time (APTT), and platelet count (PLC). Women with obstetric complications were recruited as subjects). Pregnant women without complications were included as controls.
Study Design: This is a case-control study.
Place and Duration of Study: The study took place in Obstetrics and Gynaecology Department of Specialist Hospital Sokoto and the duration was six months.
Methodology: Pregnant women aged 18–41 years (mean age 29.5 years) were recruited for the study. The determination of PT and APTT was done by manual methods using commercially prepared Agappe reagent kits, whereas PLC was done by manual methods using a haemocytometer (Improved Neubauer counting chamber). Data were analyzed using SPSS version 23.
Results: The results of PT and APTT were significantly higher among women with obstetric complications (14.26±0.23 seconds and 31.32±0.70 second) compared to normal pregnant women (13.00 ± 0.13 seconds and 29.66±0.33) (P<0.05). The PLC was significantly lower among women with obstetric complications compared to women without obstetric complications (P< 0.05).Obstetric complications in subject show a significant association when compared with PT and APTT (P< 0.05). The age group of subjects shows a significant association when compared with APTT (P< 0.05).
Conclusion: Findings from this study have shown that obstetric complications causes decrease in platelet count and prolongation in PT and APTT. There is need to assess the PT, APTT and Platelet count routinely for pregnant women to improve the ante-natal care in Specialist Hospital Sokoto.
Keywords: Coagulation parameters, women, obstetric complications, Sokoto, Nigeria