Nocardiosis Associated with Novel Agents at Relapsed Multiple Myeloma: Case Series
Atakan Turgutkaya
Division of Hematology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
Zahit Bolaman
Division of Hematology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
Emel Ceylan
Division of Pulmonology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
Murat Telli
Division of Microbiology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
Berna Gültekin Korkmazgil
Division of Microbiology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
Can Karaman
Division of Radiology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
İrfan Yavaşoğlu *
Division of Hematology, Adnan Menderes University Medical Faculty, Aydın, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Nocardiosis is a gram positive bacterial infection caused by aerobicactinomycetes. It’s nonspesific presentation and radiographic findings usually make it undiagnosed with highly fatal outcomes. The patients with intracelluler defects are prone to nocardiosis. Multiplemyelom(MM) itself is a mainly humoral deficiency disorder because of defective antibodies but recent drugs such as proteasome inhibitors and immuno modulatory drugs also cause cellular deficiency. Here we presented two definite and oneprobable pulmonary nocardiosis patients who have a diagnosis of MM, autologou shematopoetic stem cell transplant history in their past and anti myeloma therapy presently.
Keywords: Nocardiosis, multiple myeloma, gram-positive bacterial infection, actinomycetes.