Outcome of Haematological and Haemostatic Indices in Hospitalized Yellow Fever Patients at the Centre for Communicable Disease Control and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria
Sylvia Ifeoma Obu *
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Anthony Uchenna Asiodu
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Victor Azubuike Osiatuma
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Anastacia Okwudili Ojimba
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Ngozichukwuka Andrew Oburo
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Anthony Chukwuemeka Iyasele
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Efe Erhinyaye Omoyibo
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Chinyelu Ifeoma Emekekwue
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Tochi Praise Nnanna
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Justina Ifeoma Chukwumah
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Samuel Uchenna Eluaka
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Samuel Eno Edet
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Queen Adesuwa Aigbokhaede
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Ndudi Dibigbo-Ibeaji
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Obianuju Nkemjika Jisieike
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Ugoeze Francis Chinedu
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Rosemary Odion Sadoh
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Destiny Osarumwense Imade
Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: To assess the outcome of haematological and haemostatic indices in hospitalized Yellow Fever Positive patients treated using levels of full blood count, platelet count and other red cell indices at the Centre for Communicable Disease and Research (CCDCR) Federal Medical Centre, Asaba, Delta State, Nigeria.
Study Design: Retrospective observational study.
Place and Duration of Study: Centre for Communicable Disease Control and Research (CCDCR), Federal Medical Centre Asaba, Nigeria, between August and December 2020.
Methodology: Descriptive data was collected from the records of fifty-six (56) patients aged 16 – 65 years who were hospitalized and treated at the CCDCR FMC Asaba, within the months of August to December, 2020 and 56 non-Yellow Fever subjects as control subjects. The patients’ samples were previously collected and analyzed for haematological parameters (neutrophil, eosinophil, basophil, lymphocytes, monocytes, platelet count, mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC), using an automated haematology analyzer. Data collected was analyzed using SPSS version 25 and P values less than .05 were considered statistically significant.
Results: There were higher levels of total white blood cell count, eosinophil and MCH in hospitalized yellow fever patients when compared with the control group (P < 0.05). On the other hand, there was a lower level in platelet count of hospitalized yellow fever patients when compared with non-yellow fever control subjects (P < 0.05). There was no significant difference in other haematological indices assayed which appeared normal (P > 0.05).
Conclusion: In conclusion, it can be inferred that yellow fever can be associated with several haematological derangements which this study has succeeded to lay bare. Understanding these characteristics aids in planning therapy, management of patients as well as monitoring outcome.
Keywords: Haematological indices, hospitalized yellow fever positive patients, Centre for Communicable Disease Control and Research (CCDCR), Federal Medical Centre, Asaba, Delta State, Nigeria