Anti Colton-A Foeto-Neonatal Haemolytic Disesase: Diagnosis; Clinical Outcome and Family Study
G. Gessoni *
ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
L. Collodel
ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
I. Vaccara
ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
M. Pivetta
ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
T. Mancuso
IMMUCOR Italia SPA Research and Development, Mialn, Italy.
P. Lago
ULSS 2 Marca Trevigiana, Intensive Neonatal Care, Ca’ Foncello General Hospitale, Treviso, Italy.
A. Cattarozzi
ULSS 3 Serenissima, Pediatric Unit, Madonna della Navicella Hospital, Chiogga, Venice, Italy.
N. Revelli
Transfusion Medicine Department, Policlinico Hospital, Milano, Italy.
A. Barzan
ULSS 2 Marca Trevigiana Transfusion Medicine Department, Ca’ Foncello General Hospital, Treviso, Italy.
P. Cavicchioli
ULSS 3 Serenissima, Pediatric and Neonatal Unit, Dell’Angelo General Hospital. Mestre, Venice, Italy.
*Author to whom correspondence should be addressed.
Abstract
The authors report a case of neonatal haemolytic disease (HDN) attributable to maternal allo immunization to a high frequency antigen present on paternal red blood cells which have been identified as Colton-a (Coa).
The case seemed worthy of reporting not only for the relative rarity of HDN from anti Coa but for the rigorous approach followed in the immunohaematological follow-up of pregnancy and for the diagnostic effort expended in identifying the specificity of the antibody. A family study of ascendants, collaterals and descendants was also carried out using genotyping techniques.
Keywords: Anti-Coa, family study, genotyping, HDFN