Pseudo-Pelger-Huët Anomaly in Megaloblastic Anemia
Ajay Kumar Khandal *
Department of Medicine, Prathima Institute of Medical Sciences, Karimnagar, India and Usha Khandal Hospital, Mukarampura, Karimnagar, India
*Author to whom correspondence should be addressed.
Abstract
The Pelger-Huët anomaly (PHA) is a morphologic abnormality of segmentation involving the neutrophils predominantly; however, all leucocytes may be variably affected; it is an autosomal dominant condition. It has a global prevalence; with certain Indian populations having a reported prevalence as high as 1 in 300. PHA should be considered when clinical labs suggest a profound left shift in the setting of normal leucocyte count. Clinically, PHA needs differentiation from the pseudo-Pelger-Huët anomaly (PPHA), which though morphologically similar is associated with multiple disease states such as; myelodysplasia, myeloproliferative disorders, leukemias, or drugs. PPHA with megaloblastic anemia is rarely seen. Reported herein, is a case of megaloblastic anemia with PPHA.
Keywords: Pelger-Huët anomaly, pseudo–Pelger-Huët anomaly, myelodysplasia, megaloblastic anemia, vitamin B12 deficiency