Advances in the Diagnosis of Chronic Lymphoid Neoplasms in Côte d'Ivoire: Toward Improvement
Ebabh Yolande Hermance Kassi-Kablan *
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire and Laboratory of the Centre for Diagnosis and Research on AIDS and other infectious diseases (CeDReS) at Treichville University Hospital, Abidjan, Côte d’Ivoire.
Adia Eusèbe Adjambri
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Mahawa Sangaré-Bamba
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Boidy Kouakou
Department of Basic Sciences, UFR Medical Sciences, Abidjan, Côte d’Ivoire.
Ismael Kamara
Department of Basic Sciences, UFR Medical Sciences, Abidjan, Côte d’Ivoire.
Taïratou Kamagaté
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire and Laboratory of the Centre for Diagnosis and Research on AIDS and other infectious diseases (CeDReS) at Treichville University Hospital, Abidjan, Côte d’Ivoire.
Marie France Edjeme Meledje
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Jocelyne Rebecca N’Guessan-Blao
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Eugénie Mireille Yayo-Ayé
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Emma Aha N’Draman-Donou
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
Duni Sawadogo
Hematology Teaching Unit; General Biology, UFR of Pharmaceutical and Biological Sciences, University Felix Houphouët Boigny, Abidjan, Côte d’Ivoire.
*Author to whom correspondence should be addressed.
Abstract
This study aims to provide a comprehensive overview of Chronic Lymphoproliferative Disorders (CLPDs) in Côte d'Ivoire, focusing on recent advancements in diagnostic techniques to improve patient management. The study characterizes CLPDs in Côte d'Ivoire, highlighting advancements in diagnostic methods that may enhance patient care. A cross-sectional study was conducted, including 51 patients with lymphocytosis >5000/mm³. Cytological and immunophenotypic analyses were performed using flow cytometry to identify and classify CLPDs. The results showed that among the 51 cases of CLNs identified, B-cell proliferations accounted for 82%, while T-cell proliferations constituted 18%. Chronic lymphocytic leukaemia (CLL) was predominant. Immunophenotyping revealed distinct marker profiles, enabling subtype differentiation. While cytology remains relevant, emphasis was placed on integrating immunophenotyping and molecular techniques for accurate diagnosis. The combination of flow cytometry with other molecular biology techniques has been recognized as a significant advancement in the field. Further integration of cytogenetics and molecular biology aims to refine diagnostic accuracy and treatment strategies.
Keywords: Chronic lymphoid neoplasms, immunophenotyping, flow cytometry, haematology, Côte d'Ivoire