P-selectin Marker in Venous Thromboembolism
Jumala Nikhitha
Kamineni Academy of Medical Sciences and Research Centre, L.B Nagar, Hyderabad-500068, Telangana, India.
Amulya Kalidindi
Kamineni Academy of Medical Sciences and Research Centre, L.B Nagar, Hyderabad-500068, Telangana, India.
Sandeep Kumar Tipparthi
Kamineni Academy of Medical Sciences and Research Centre, L.B Nagar, Hyderabad-500068, Telangana, India.
RajKumar HRV
Kamineni Academy of Medical Sciences and Research Centre, L.B Nagar, Hyderabad-500068, Telangana, India.
Guru Prasad Manderwad *
Kamineni Academy of Medical Sciences and Research Centre, L.B Nagar, Hyderabad-500068, Telangana, India.
*Author to whom correspondence should be addressed.
Abstract
Venous thrombosis is a life threatening disease associated with high morbidity and mortality. Predisposing factors of venous thrombosis associated with obesity, age, varicose veins etc. There is an interaction between the thrombosis and inflammation. P selectin unregulated glycoprotein, has an ability to bind to the ligand of leucocytes and platelets. Modulation contributes of initial thrombus, plays an important role in development and progression of thromobocytic events and may acts as a biomarker for venous thrombo embolism.
Keywords: P-selectin marker, venous thrombosis, morbidity, obesity, inflammation, thrombosis